Imidacloprid na Moxidectin Spot-on Solution (maka nkịta)

【Isi mgwa ihe】

Imidacloprid, Moxidectin

【Ọdịdị】

Mmiri mmiri na-acha odo odo na agba aja aja.

【Pharmacologic omume】

Ọgwụ antiparasitic.

Pharmacodynamics:Imidacloprid bụ ọgbọ ọhụrụ nke ọgwụ ahụhụ nicotine nwere chlorinated. Ọ nwere nnukwu mmekọrịta maka postsynaptic nicotinic acetylcholine receptors na etiti ụjọ nke ụmụ ahụhụ, ma nwee ike igbochi ọrụ acetylcholine, na-eduga parasaiti mkpọnwụ na ọnwụ. Ọ dị irè megide fleas ndị okenye na fleas na-eto eto na ọkwa dị iche iche, ma na-enwekwa mmetụta igbu egbu na fleas na-eto eto na gburugburu ebe obibi. Usoro nke moxidectin yiri nke abamectin na ivermectin, ọ na-enwekwa mmetụta dị mma na-egbu egbu na nje ndị dị n'ime na n'èzí, karịsịa nematodes na arthropods. Ntọhapụ nke butyric acid (GABA) na-abawanye ike ya na ndị na-anabata postsynapti, na ọwa chloride ga-emepe. Moxidectin nwekwara selectivity na nnukwu mmekọrịta maka ọwa glutamate-mediated chloride ion channels, si otú ahụ na-etinye aka na mgbasa ozi neuromuscular, na-atụrụ ndụ ma na-akpọnwụ parasaiti, na-eduga na ọnwụ nke nje nje. Inhibitory interneurons na excitatory moto neurons na nematodes bụ saịtị ọrụ ya, ebe na arthropods ọ bụ njikọ neuromuscular. Ngwakọta nke abụọ nwere mmetụta synergistic.

Pharmacokinetics:Mgbe nchịkwa nke mbụ gasịrị, a na-ekesa imidacloprid ngwa ngwa n'elu ahụ nkịta ahụ n'otu ụbọchị ahụ, ma nọgide na-adị n'elu ahụ n'oge oge nchịkwa 4-9 ụbọchị mgbe nchịkwa gasịrị, ntinye plasma nke moxidectin n'ime nkịta ruru ọkwa kachasị elu. A na-ekesa n'ime ahụ dum n'ime otu ọnwa ma jiri nwayọọ nwayọọ na-emepụta ma wepụ ya.

【Ngosipụta】
N'ihi na mgbochi na ọgwụgwọ nke esịtidem na mpụga parasitic ọrịa na nkịta. Mgbochi na ọgwụgwọ nke flea infestations (Ctenocephalic canis), ọgwụgwọ nke lice infestations (Catonicus canis), ọgwụgwọ nke ntị mite infestations (ltchy otica), canine sarcoids (Scabies mites), na demodicosis (Demodex canis), maka ọgwụgwọ nke Angiostrongylus na ọrịa nematode eriri afọ (ndị okenye, ndị na-eto eto na L4larvae nke Toxocara canis, Ancylostoma canis, na Ancylocephalus larvae; ndị okenye nke Toxocara lionis na Trichocephala vixensis). Enwere ike iji ya mee ihe dị ka ọgwụgwọ adjuvant nke nfụkasị dermatitis kpatara fleas.

【Ojiji na usoro onunu ogwu】
Ojiji nke mbata, dobe ngwaahịa a na akpụkpọ ahụ site n'azụ nkịta n'etiti ubu abụọ ruo n'úkwù, ma kewaa ya n'ime ebe 3-4. Otu dose, maka nkịta, kwa 1kg nke arọ ahụ, 10mg imidacloprid na 2.5mg nke moxidectin, nke kwekọrọ na 0.1ml nke ngwaahịa a. N'oge ọgwụgwọ ma ọ bụ prophylaxis, a na-atụ aro inye ya otu ugboro n'ọnwa. Gbochie nkịta ịracha.

【Mmetụta】

(1) N'ọnọdụ ndị mmadụ n'otu n'otu, ngwaahịa a nwere ike ibute mmeghachi ahụ nfụkasị nke mpaghara, na-ebute itching na-adịru nwa oge, nrapanye ntutu, erythema ma ọ bụ vomiting. Mgbaàmà ndị a na-apụ n'anya na-enweghị ọgwụgwọ.

(2) Mgbe nchịkwachara, ọ bụrụ na anụ ahụ rachaa ebe nchịkwa ahụ, mgbaàmà akwara na-adịru nwa oge nwere ike ịpụta mgbe ụfọdụ, dị ka mkpali, ịma jijiji, mgbaàmà anya (ụmụ akwụkwọ dilated, reflexes pupillary, na nystagmus), iku ume na-adịghị mma, salivation, na mgbaàmà dị ka vomiting. ; mgbanwe omume na-adịru nwa oge mgbe ụfọdụ dị ka enweghị mmasị imega ahụ, obi ụtọ, na enweghị agụụ na-eme.

【Mkpachapụ anya】

(1) Ejila maka ụmụ nkịta n'okpuru izu asaa. Nkịta nwere ihe nfụkasị ngwaahịa a ekwesịghị iji ya. Nkịta dị ime na nke na-enye nwa kwesịrị ịgbaso ndụmọdụ ọgwụgwọ anụmanụ tupu eji ya.

(2) Nkịta nọ n'okpuru 1kg ga-agbaso ndụmọdụ ọgwụgwọ anụmanụ mgbe ị na-eji ngwaahịa a.

(3) Ngwaahịa a nwere moxidectin (macrocyclic lactone), yabụ mgbe ị na-eji ngwaahịa a na collies, nkịta atụrụ ochie nke bekee na ụdị ndị metụtara ya, a ga-akwụrịrị nlebara anya pụrụ iche iji gbochie nkịta ndị a ịracha nke a.ngwaahịa site n'ọnụ.

(4)Nkịta na-arịa ọrịa na nkịta na-adịghị ike anụ ahụ kwesịrị ịgbaso ndụmọdụ ndị dọkịta na-agwọ ọrịa mgbe ha na-eji ya.

(5) E kwesịghị iji ngwaahịa a na nwamba.

(6) N'oge eji ngwaahịa a, ekwela ka ọgwụ na tube ọgwụ na-emetụ anya na ọnụ anụ ụlọ ma ọ bụ anụmanụ ndị ọzọ. Emetụla ma ọ bụ kpụzie ntutu isi ruo mgbe ọgwụ akpọnwụwo.

(7) Mgbe ụfọdụ 1 ma ọ bụ 2 ikpughe nkịta na mmiri n'oge oge nchịkwa agaghị emetụta mmetụta nke ọgwụ ahụ nke ọma. Agbanyeghị, iji ncha ntutu mgbe niile maka ịsa ahụ ma ọ bụ imi n'ime mmiri site na nkịta nwere ike imetụta ịdị mma nke ọgwụ ahụ.

(8)Chebe ụmụaka ka ha ghara ịkọrọ ngwaahịa a.

(9) Echekwala ihe karịrị 30℃,ma ejikwala ihe karịrị ụbọchị ngafe akara.

(10) Ndị nwere ihe nfụkasị ngwaahịa a ekwesịghị inye ya.

(11) Mgbe ị na-enye ọgwụ ahụ, onye ọrụ kwesịrị izere kọntaktị na akpụkpọ ahụ, anya na ọnụ nke ngwaahịa a, ma ghara iri ihe, ịṅụ ihe ọṅụṅụ ma ọ bụ anwụrụ ọkụ; mgbe nlekọta ahụ gasịrị, a ga-asacha aka aka. Ọ bụrụ na ọ na-efesa na mberede na akpụkpọ ahụ, were ncha na mmiri saa ozugbo; ọ bụrụ na ọ fesa n'anya na mberede, were mmiri sachaa ya ozugbo.

(12) Ka ọ dị ugbu a, ọ nweghị ọgwụ nnapụta akọwapụtara maka ngwaahịa a; ọ bụrụ na ejiri ezighi ezi loro, unyi na-arụ ọrụ ọnụ nwere ike inye aka detoxification.

(13) Ihe mgbaze dị na ngwaahịa a nwere ike imerụ ihe ndị dị ka akpụkpọ anụ, ákwà, plastik na ihe ndị e sere ese. Tupu saịtị nchịkwa akpọọ nkụ, gbochie ihe ndị a ịkpọtụrụ saịtị nchịkwa

(14) Ekwela ka ngwaahịa a banye n'elu mmiri.

(15) Ekwesịrị ikpochapụ ọgwụ ndị a na-ejighị mee ihe na ihe nkwakọ ngwaahịa n'ụzọ na-adịghị njọ dịka ihe mpaghara chọrọ.

【Mwepụ  oge】Ọ dịghị

【Nkọwapụta】

(1) 0.4ml: Imidacloprid 40mg +Moxidectin 10mg

(2) 1.0ml: Imidacloprid 100mg+Moxidectin 25mg

(3)2.5ml: Imidacloprid 250mg +Moxidectin 62.5mg

(4)4.0ml: Imidacloprid 400mg+Moxidectin 100mg

 【Nchekwa】

E mechiri, echekwara na ụlọ okpomọkụ.

【Ndụ nchekwa】

Afọ 3